At the moment, I’m studying the Sickle Cell Disease. And this idea came to mind. I’m sure it has already been thought of or done but I’d like to share.
From what I know, the Haemoglobin in Red Blood Cells allow them to change their shape, whilst they traverse through the body.
But with Sick Cell Disease, they are usually sickle shaped. Because of this, they can get a higher chance of strokes, or numbness in arms from arteries or veins getting blocked up due to their shape.
I thought of this…
People with this illness can’t get Malaria, as the cell shatters when it comes into contact with the protist. So what if, though this would be difficult, there was a vaccine designed to genetically modify the Haemoglobin in Red Blood Cells and to cause the White Blood Cells to release a hormone triggering red blood cells to change into sickle shapes whenever Malaria to detected by the White Blood Cells? The white blood cells would detect the blood cells, this releasing a modified hormone that triggers the red blood cells to change shape, until the malaria dies out, due to not being able to continue its life cycle, and then the Red Blood Cell could utilise the modified Haemoglobin to return to its original shape so that the chance of experiencing side effects of sickle cell disease is lower. Besides all of this, it theoretically shouldn’t cause too much harm to the actual Haemoglobin, as it can naturally change its shape anyway.
And technically, this method could also be used as a cure to not only just Malaria, but to use a similar method to widen the blood cells in those who have sickle cell disease anyway. A possible cure?
The only downside is that designing these hormones and ways to modify core parts of the body’s circulatory system will be difficult and most likely rejected by the body and seen as imposters.
I’m not a professional in medicine or vaccinations, but I wanted people thoughts on this idea, it might be unrealistic but I’d like to know more about this subject. The more you know, after all!
Source: Original link