I have recently read David Sinclair's book Lifespan: Why We Age—and Why We Don't Have To. David is a Harvard scientist researching ageing, with particular focus on sirtuins. Most of this book is a summary of the state of research of ageing, and the push towards rebranding it as a disease. From a medical perspective, Sinclair says that he makes no recommendations to the public, but he incorporates the following drugs and supplements into his routine (and so do, apparently, a significant amount of his scientific colleagues and family):
I take 1 gram (1,000 mg) of NMN every morning along with 1 gram of resveratrol (shaken into my homemade yogurt) and 1 gram of metformin. I take a daily dose of vitamin D, vitamin K2, and 83 mg of aspirin.
Most of the research so far on NMN (nicotinamide mononucleotide) is in mice models, showing an increase in NAD+ and longevity/increased lifespan.
As medical practitioners, what are your thoughts on this supplement (NMR, or resveratrol), the research behind it, whether you'd recommend it to patients (or yourself!) without further trails, and the state of aging as a research topic in general? Do you have any anecdotes of patients asking to be prescribed metformin without pre-existing diabetes?
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