Physical and Medical Barriers That Prevent Weight Reduction

Getting in shape and losing weight can be extremely physically challenging. However, it might be even more mentally challenging. We have all experienced setbacks when it comes to attempting to achieve our optimal health and wellness. In this video we will explore how to overcome mental weight loss barriers and how to stay focused & on track with your fitness goals. By mastering our minds, we can reach our goals and maximize our individual healthcare..
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Why do you gain weight with antidepressants and mood stabilizers?
In this video I discuss two way. One way is by blocking histamine 1 receptors. We usually think of histamine as something that is associated with allergies and your immune response. If you’re exposed to something your body is sensitive to, you get a histamine response that can look like itching, runny nose or even shortness of breath. And if you take an antihistamine like Benadryl, it slows the allergic reaction and you feel better. That’s how it works from the neck down. Histamine acts differently in your brain. In certain parts of your brain, it’s responsible for wakefulness or your ability to be alert. That’s why if you take an anti-histamine it may reduce your allergic reaction, but if it crosses the blood brain barrier, it can also make you sleepy because it’s blocking histamine’s stimulating effect in your brain. There are four histamine receptors, I’m going to talk about H1 receptors..
A second mechanism is blocking the 5HT 2c receptors. This is just a type of serotonin receptor. It’s been shown in mice that if you activate their 5HT2c receptors, they lose weight because they eat less. And if you block the receptor they became obese. Many of the newer antipsychotic medications block this receptor. Of all the antipsychotic medications, the worst offenders when it comes to weight gain are olanzapine, clozapine and quetiapine. And all three of these medications block 5HT2c..
In this video I also discuss what you can do to offset the weight gain..
Want to know more about mental health and self-improvement? On this channel I discuss topics such as bipolar disorder, major depression, anxiety disorders, attention deficit disorder (ADHD), relationships and personal development/self-improvement. If you don’t want to miss a video, click here to subscribe. https://goo.gl/DFfT33.
References.
He M, Deng C, Huang XF. The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain. CNS Drugs. 2013;27(6):423–434..
Nikhil Nihalani, Thomas L. Schwartz, Umar A. Siddiqui, and James L. Megna, “Weight Gain, Obesity, and Psychotropic Prescribing,” Journal of Obesity, vol. 2011, Article ID 893629, 9 pages, 2011.
Halford JC1, Harrold JA. 5-HT(2C) Receptor agonists and the control of appetite. Handbook Exp Pharmacol. 2012;(209):349-56..
Dayabandara M, Hanwella R, Ratnatunga S, Seneviratne S, Suraweera C, de Silva VA. Antipsychotic-associated weight gain: management strategies and impact on treatment adherence. Neuropsychiatr Dis Treat. 2017;13:2231–2241..
Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.

Overweight and obese patients frequently feel stigmatized in health care settings, and face stereotypes and prejudice from health care providers..
These stigmatizing experiences (also called ‘weight bias’) jeopardize patients’ emotional and physical health. The Rudd Center for Food Policy and Obesity at Yale University (www.yaleruddcenter.org) has released this new video in response to a growing concern about weight bias in health care. The video, hosted by celebrity and activist Emme and featuring Rudd Center experts including Dr. Rebecca Puhl and Dr. Kelly Brownell, uses expert commentary and dramatic representation to increase awareness of bias and stigma that overweight and obese patients encounter in health care. Equally importantly, the video presents a range of practical strategies to help providers reduce bias in their clinical practice, and to optimize the health care experience for their overweight and obese patients.

Getting the whole family involved in becoming more active and making healthy food choices can make it easier to lose weight and prevent type 2 diabetes.

Webinar Speakers:
Dr. Jessica Unick, PhD, Assistant Professor (Research), Brown University Medical School.
Leslie Curtis, MA, Director, Weight-control Information Network NIDDK, National Institutes of Health.
Learning objectives attendees will better be able to:
Identify and understand the national physical activity guidelines.
Recognize several common physical activity myths.
Acknowledge barriers to physical activity participation and develop strategies to help patients overcome these barriers.
Identify physical activity web content and tools from NIDDK and other sources.
For more information, visit https://www.niddk.nih.gov/

This video provides scientific evidence about why exercise should NOT be used alone for weight loss. The video discusses pragmatic, safe and evidence-based approaches for weight loss. I also give my opinion on the many weight loss diets out there..
References for further reading:
1) Franz, M. J., VanWormer, J. J., Crain, A. L., Boucher, J. L., Histon, T., Caplan, W.,… & Pronk, N. P. (2007). Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. Journal of the American Dietetic Association, 107(10), 1755-1767..
2) Willis, L. H., Slentz, C. A., Bateman, L. A., Shields, A. T., Piner, L. W., Bales, C. W.,… & Kraus, W. E. (2012). Effects of aerobic and/or resistance training on body mass and fat mass in overweight or obese adults. Journal of applied physiology, 113(12), 1831-1837..
3) Ross, R., Dagnone, D., Jones, P. J., Smith, H., Paddags, A., Hudson, R., & Janssen, I. (2000). Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: a randomized, controlled trial. Annals of internal medicine, 133(2), 92-103..
4) Church, T. S., Martin, C. K., Thompson, A. M., Earnest, C. P., Mikus, C. R., & Blair, S. N. (2009). Changes in weight, waist circumference and compensatory responses with different doses of exercise among sedentary, overweight postmenopausal women. PloS one, 4(2), e4515. doi:10.1371/journal.pone.0004515.
5) Paravidino VB, Mediano MFF, Hoffman DJ, Sichieri R (2016) Effect of Exercise Intensity on Spontaneous Physical Activity Energy Expenditure in Overweight Boys: A Crossover Study. PLOS ONE 11(1): e0147141. https://doi.org/10.1371/journal.pone.0147141.
6) Fogelholm, M., & Kukkonen‐Harjula, K. (2000). Does physical activity prevent weight gain–a systematic review. Obesity reviews, 1(2), 95-111..
7) Moholdt, T., Wisløff, U., Lydersen, S., & Nauman, J. (2014). Current physical activity guidelines for health are insufficient to mitigate long-term weight gain: more data in the fitness versus fatness debate (The HUNT study, Norway). Br J Sports Med, 48(20), 1489-1496..
8) Klem, M. L., Wing, R. R., McGuire, M. T., Seagle, H. M., & Hill, J. O. (1997). A descriptive study of individuals successful at long-term maintenance of substantial weight loss. The American journal of clinical nutrition, 66(2), 239-246..
A nice article about how to address physical activity in clinic consultations: Sallis, R., Franklin, B., Joy, L., Ross, R., Sabgir, D., & Stone, J. (2015). Strategies for promoting physical activity in clinical practice. Progress in cardiovascular diseases, 57(4), 375-386.

Alisa is a doctoral researcher in clinical health psychology at UCL who has taught and given talks across the country. Her work covers new areas of eating disorder research at the intersection of the conscious and the unconscious. Seven years of experience in journalism has lent itself to an interest in public engagement and the bridging of the gap between the scientific community and the public at large. Her core interest is in understanding how we eat, what we believe about weight loss, and how a ‘diet’ is just ‘die’ with a T…
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