Inosine Benefits, Negative Effects, Dosage, and Interactions

In a new study published in the journal Nature Medicine, researchers behind the Healthy Nevada Project® suggest that community-based genetic screening has the potential to efficiently identify individuals who may be at increased risk for three common inherited genetic conditions known to cause several forms of cancer and increased risk for heart disease or stroke..
In 2018, the Healthy Nevada Project® (the largest, community-based population health study combining genetic, clinical, environmental, and social data) started notifying consenting study participants who have certain genetic variants that predispose them to the Centers for Disease Control and Prevention (CDC) Tier 1 genetic conditions. The study focused on identifying carriers of these conditions, which include Hereditary Breast and Ovarian Cancer, Lynch Syndrome, and Familial Hypercholesterolemia, because they are the most common conditions and early detection and treatment could significantly lower morbidity and mortality..
Initial results from almost 27,000 study participants showed that 90% of carriers of the CDC Tier 1 genetic conditions were not previously identified in a clinical setting. The authors conclude that population genetic screening would identify at-risk carriers not identified during routine care..
“Our first goal was to deliver actionable health data back to the participants of the study and understand whether or not broad population screening of CDC Tier 1 genomic conditions was a practical tool to identify at-risk individuals,” explained Joseph Grzymski, Ph.D., the principal investigator of the Healthy Nevada Project®, a research professor at the Desert Research Institute (DRI), chief scientific officer for Renown Health and lead author of the study..
“Now, two years into doing that, it is clear that the clinical guidelines for detecting risk in individuals are too narrow and miss too many at-risk individuals.” Within the group of 26,906 Healthy Nevada Project® participants that Grzymski’s research team studied, 358 (1.33%) were carriers for CDC Tier 1 conditions. However, only 25% of those individuals met clinical guidelines for genetic screening. Additionally, more than 20% of the carriers already had a diagnosis of disease-relevant to their underlying genetic condition..
Most notably, the study found that of the 273 participants who were carriers of the CDC Tier 1 genetic conditions and had clinical record information, only 22 individuals showed any previous suspicion of their underlying genetic conditions.

In Part 6 of Pasture Project’s video series on adaptive grazing, we focus on the varied benefits of grazing multiple species of livestock. Animals such as pigs and sheep differ from cattle in key ways, from the degree of impact they have on a pasture to the microbial communities they introduce to the soil. Thanks to Dr. Allen Williams (Pasture Project & Grass Fed Insights, LLC) and Dan Jenniges (Jenniges Hidden Acres) for their contributions to this video..
Filming and editing by Windborne Media.

In this episode Marc:
-Discloses his HRT dosing.
-Dedicates the prep to Tracy Otto and Domestic Abuse and Violence DONATE TO TRACY HERE: https://www.gofundme.com/f/justicefortracy.
-Moving to Tennessee.
-Heavy Hamstring Training.
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The Lifting Dermatologist daily supplement stack..
What supplements I take daily?
My personal pre-, intraand post workout supplements and my personal skin care routine..
#theliftingdermatologist #liftingdermatologist.
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Links to What I use daily:
Where I buy my Vitamin C: https://amzn.to/3diC4lb.
Where I buy my Zinc gluconate: https://amzn.to/3evM0ZK.
Link: Selenium: https://amzn.to/2ClwoKd.
Where I buy my N-Acetyl Cysteine: https://amzn.to/2YUrJ9H.
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Q10 Ubiquinol 100mg: https://amzn.to/2V2rFnn.
Vitamin D3: https://amzn.to/2V3VbZV.
Omega-3 Fish Oil: https://amzn.to/3ewJrad.
Vitamin K2: https://amzn.to/3fGcZ5e.
What I take for my joints: Glucosamine & Chondroitin: https://amzn.to/2Bt4XOs.
Curcuma 500mg: https://amzn.to/310IsLb.
Where I buy my Pre-workout: Mucle Pharm Assault: https://amzn.to/2UYRK6I.
Intra-workout: Dextrose powder: https://amzn.to/2V40Uin.
Potassium Citrate: https://amzn.to/31575qb.
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In his discussion “Integration of Telomere Length and Mutations on Treatment and Transplant Responses in Pulmonary Fibrosis,” Imre Noth, MD of the University of Virginia shares the definition of “precision/personalized” medicine, and discusses past studies and the PRECISIONS study..
Social media platforms
Twitter @PFFORG.
Facebook @PFFORG.
Instagram @PFFORG.
LinkedInPulmonary Fibrosis Foundation.
Please note that any information contained in this presentation is for informational and/or educational purposes only. It is not intended to be a substitute for professional medical advice. Always consult your personal physician or health care provider with any questions you may have regarding your specific medical condition..
This presentation is protected by U.S. and International copyright laws. Reproductions and distribution of this presentation without written permission from the Pulmonary Fibrosis Foundation is prohibited..
© 2020 Pulmonary Fibrosis Foundation

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Inosine is a purine nucleoside that serves as a building block for DNA and RNA. It was originally studied in the 1970s as a potential ergogenic aid due to its involvement in the ATP cycle. However, after a trio of studies in the 1990s demonstrated that inosine had NO BENEFICIAL impact on performance, it stopped being considered as a worthy addition to sports nutrition supplements..
Until now……
References:
1) Williams, M. H., Kreider, R. B., Hunter, D. W., Somma, C. T., Shall, L. M., Woodhouse, M. L., & Rokitski, L. (1990). Effect of inosine supplementation on 3-mile treadmill run performance and VO2 peak. Medicine and Science in Sports and Exercise, 22(4), 517–522..
2) Williams, M. H. (1992). Ergogenic and ergolytic substances. Medicine & Science in Sports & Exercise, 24(Supplement), 344???348. doi:10.1249/00005768-199209001-00008.
3) Starling, R. D., Trappe, T. A., Short, K. R., Sheffield-Moore, M., Jozsi, A. C., Fink, W. J., & Costill, D. L. (1996). Effect of inosine supplementation on aerobic and anaerobic cycling performance. Medicine and Science in Sports and Exercise, 28(9), 1193–1198..
4) McNaughton, L., Dalton, B., & Tarr, J. (1999). Inosine Supplementation Has No Effect on Aerobic or Anaerobic Cycling Performance. International Journal of Sport Nutrition, 9(4), 333–344. doi:10.1123/ijsn.9.4.333.
5) Fang P, Li X, Luo JJ, Wang H, Yang XF. A Double-edged Sword: Uric Acid and Neurological Disorders. Brain Disord Ther. 2013;2(2):109..
6) Cheng W, Wen S, Wang Y, et al. The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort. Medicine (Baltimore). 2017;96(50):e8953..
7) Perlstein TS, Gumieniak O, Williams GH, et al. Uric acid and the development of hypertension: the normative aging study. Hypertension 2006;48:1031–6.
8) Markowitz CE, Spitsin S, Zimmerman V, et al. The treatment of multiple sclerosis with inosine. J Altern Complement Med. 2009;15(6):619-25..
9) McConell, G. K., Shinewell, J., Stephens, T. J., Stathis, C. G., Canny, B. J., & Snow, R. J. (2005). Creatine Supplementation Reduces Muscle Inosine Monophosphate during Endurance Exercise in Humans. Medicine & Science in Sports & Exercise, 37(12), 2054–2061. oi:10.1249/01.mss.0000179096.03129.a4.
10) McConell, G., Snow, R. J., Proietto, J., & Hargreaves, M. (1999). Muscle metabolism during prolonged exercise in humans: influence of carbohydrate availability. Journal of Applied Physiology, 87(3), 1083–1086. https://doi.org/10.1152/jappl.1999.87.3.1083.
11) Devous, M. D. S., & Lewandowski, E. D. (1987). Inosine preserves ATP during ischemia and enhances recovery during reperfusion. The American Journal of Physiology, 253(5 Pt 2), H1224-33. https://doi.org/10.1152/ajpheart.1987.253.5.H1224.
12) Miyaki, T., Retiveau-Krogmann, A., Byrnes, E., & Takehana, S. (2015). Umami Increases Consumer Acceptability, and Perception of Sensory and Emotional Benefits without Compromising Health Benefit Perception. Journal of Food Science, 81(2), S483–S493. doi:10.1111/1750-3841.13195.
13) Yan, J., Liu, P., Xu, L., Huan, H., Zhou, W., Xu, X., & Shi, Z. (2018). Effects of exogenous inosine monophosphate on growth performance, flavor compounds, enzyme activity, and gene expression of muscle tissues in chicken. Poultry Science, 97(4), 1229–1237. https://doi.org/10.3382/ps/pex415.
14) Sarvestani ST, Tate MD, Moffat JM, et al. Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8. J Virol. 2014;88(2):799-810..
15) Alseth, I., Dalhus, B., & Bjørås, M. (2014). Inosine in DNA and RNA. Current Opinion in Genetics & Development, 26, 116–123. https://doi.org/https://doi.org/10.1016/j.gde.2014.07.008.
16) Mackie, A.M. (1987). Identification of the gustatory feeding stimulants. In: Chemoreception in Fishes. (ed. T.J. Hara). Elsevier Scientific Publishing Co., Amsterdam, pp. 275-291.
17) Takeda, M. Takii, K. & Matsui, K. (1984). Identification of feeding stimulants for juvenile eel. Bull. Jap. Soc. Scient. Fish., 50: 645-651

30 Health Benefits and 12 Drug Interactions of Vitamin D:
References:
Books:
1) Harrison`s Principals of Internal Medicine, edition 20..
2) Harrison`s Principals of Internal Medicine, edition 18..
3) Textbook of Medical Physiology, Guyton and Hall, edition 13..
4) LANGE, Harper`s Illustrated Biochemistry, 31th edition, 2018..
5) Earl Mindell`s New Vitamin Bible..
6) The Encyclopedia of Natural Medicine, edition 3..
7) Goodman and Gilman`s The Pharmacological Basis of Therapeutics (Workbook and Casebook), 2016..
8) Goodman and Gilman`s Manual of Pharmacology and Therapeutics..
9) Katzung`s Basic and Clinical Pharmacology, edition 14..
10) The Natural Pharmacy, Alan R. Gaby, MD..
11) Pathophysiology; Concepts of Altered Health States, Lippincott, edition 5..
12) Prescription for Natural Cures, James F. Balch, MD..
13) Lehne`s Pharmacotherapeutics for Nurse Practitioners and Physician Assistants, 2018..
14) LANGE, Greenspan’s Basic & Clinical Endocrinology, 10the edition..
15) LANGE, Current Medical Diagnosis and Treatment 2020..
Websites:
1) Canadian Academy of Sports Nutrition.
https://www.caasn.com.
2) National Institutes of Health (NIH).
https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/.
Articles:
1) Canadian Vitamin D study: Higher Vitamin D levels could save 37,000 lives a.
year.
https://www.newswire.ca/news-releases/canadian-vitamin-d-study-higher-vitamin-d-levels-could-save-37000-lives-ayear-539683041.html.
2) Is vitamin D an important biomarker for symptom severity in COVID-19?
https://hospitalhealthcare.com/covid-19/is-vitamin-d-an-important-biomarker-for-symptom-severity-in-covid-19/?fbclid=IwAR1sgedkiMOBbqw2niz5s1KF5COgazqbC5kblxD-DeFhombMZoxRDszTJm0.
3) Vitamin D.
http://pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000340.
4) A possible correlation between vitamin D deficiency and loss of smell: 2 case reports.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315864/.
5) Impact of vitamin D status on statin-induced myopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644425/.
6) Statins and vitamin D.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408997/.
7) Are statins analogues of vitamin d?
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(06)69506-8/fulltext.
8) Acute Respiratory Distress Syndrome and vitamin D.
https://pubmed.ncbi.nlm.nih.gov/28446599/?from_term=statins+and+vitamin+D+supplemntation&from_pos=6.
9) Effects of Vitamin D Supplementation in Atorvastatin-Treated Patients: A New Drug Interaction With an Unexpected Consequence.
https://pubmed.ncbi.nlm.nih.gov/18754003/.
10) The Role of Vitamin D in Disease Progression in Early Parkinson’s Disease.
https://pubmed.ncbi.nlm.nih.gov/28984616/.
11) Role of Vitamin D in Parkinson’s Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349248/.
12) Effect of Cimetidine on Hepatic Vitamin D Metabolism in Humans.
https://pubmed.ncbi.nlm.nih.gov/2253823/.
13) The Association Between Drugs Frequently Used by the Elderly and Vitamin D Blood Levels: A Review of Observational and Experimental Studies.
https://pubmed.ncbi.nlm.nih.gov/24385337/.
14) Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158648/.
15) Vitamin D deficiency and fatigue: an unusual presentation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628075/.
16) The potential role of serum vitamin D level in migraine headache: a case–control study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709376/.
17) Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075301/.
18) Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247472/.
19) The Role of Vitamin D in Non-Scarring Alopecia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751255/.
20) Vitamin D Supplementation to Prevent Acute Respiratory Tract Infections: Systematic Review and Meta-Analysis of Individual Participant Data.
https://pubmed.ncbi.nlm.nih.gov/28202713/?fbclid=IwAR16mcU-D7gKxFtahrDCiETF7TnEOkRIfsaFHvHGbi3yvLAXxtYiAQsTTfo.
21) Association between Vitamin D Deficiency and Primary Cesarean Section.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681281/.
22) Effects of Vitamin D on Skeletal Muscle and Athletic Performance.
https://pubmed.ncbi.nlm.nih.gov/29561306/?from_term=vitamin+D+and+sports+injury&from_pos=1.
23) Impact of Vitamin D in Sports: Does Vitamin D Insufficiency Compromise Athletic Performance?
https://pubmed.ncbi.nlm.nih.gov/28219093/?from_term=vitamin+D+and+sports+injury&from_pos=3.
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